method for isolating a central sedative effects isovaleriansaeureesters from waessrigen valerian extracts

摘要

The invention comprises an Isovaleric acid ester of the molecular formula C22H30O8 molecular weight 422.46 having a U.V. spectrum with max1 = 256 mm (e = 15010) and max2 = 204 mm (e = 3800) in methanol and IR- and NMR-spectra according to Figs. 1 and 2 (not shown) and the process for the isolation of the above Isovaleric acid ester sedative comprising the chromographic separation from a non-aqueous valerian extract, of the isovaleric acid ester sedative on aluminium oxide which has been partially inactivated by treatment in a non-aqueous medium with a carboxylic acid having from 2-7 carbon atoms in the molecule, and elution therefrom with a non-aqueous solvent preferably of the first range of the eluotropic series or a corresponding isoeluotropic mixture.ALSO:Aluminium oxide which has been partially inactivated by treatment of a commercial aluminium oxide, preferably a neutral or basic aluminium oxide standardized according to Brockman, in a non-aqueous medium, preferably in a lipophilic solvent. Dioxane, acetone or an ester such as amylacetate or glycerine monoacetate or mixtures thereof may be added during the treatment of the aluminium oxide. The inactivated aluminium oxide is used in the isolation of an isovaleric acid ester (see Division C2).ALSO:The invention comprises an Isovaleric acid ester of the molecular formula C22H30O8 molecular weight 422.46 having a UV-spectrum with max1 = 256 mm (e = 15010) and max2 = 204 mm (e = 3800) in methanol and IR-and NMR-spectra according to Figs. 1 and 2 respectively of the accompanying drawings and the process for the isolation of the above Isovaleric acid ester sedative comprising the chromographic separation from a non aqueous valerian extract, of the isovaleric acid ester sedative on aluminium oxide which has been partially inactivated by treatment in a non aqueous medium with a carboxylic acid having from 2-7 carbon atoms in the molecule, and elurion therefrom with a non aqueous solvent preferably of the first range of the eluotropic series or a corresponding isoeluotropic mixture.