method for increasing the optical purity of the optically active lysinmonohydrochlorid

摘要

1,169,311. Increasing optical purity of Lysine monohydrochloride. STAMICARBON N.V. 1 Jan., 1968 [11 Jan., 1967], No. 94/68. Heading C2C. The optical purity of optically active lysine monohydrochloride containing DL-lysine monohydrochloride is increased by mixing the lysine- HC1 in the solid state with water for a period of time less than that required to effect an equilibrium state, and separating the remaining solid phase from the liquid phase which then contains optically-active lysine HCl of increased optical purity. The mixing is preferably performed at 40-80‹ C. and the solid lysine-HCl may contain water of crystallization. The amount of water used advantageously corresponds to the amount which would be needed to form a saturated or substantially saturated solution of the available pure L- or D-lysine-HCl at a temperature equal to that at which the mixing of the solid lysine-HCl with the water is terminated.