Organic nitrate bile acid inclusion compounds

摘要

Inclusion compounds of bile acids and organic nitrates selected from glyceryl trinitrate, penta-erythritol tetranitrate, mannitol hexanitrate, erythritol tetranitrate and isosorbide dinitrate. - Complexes are readily absorbed from the gastro-intestinal tract. The organic nitrates above are mainly used in treatment of angina pectoris. - Solution of bile acid and organic nitrate in inert solvent which dissolves both. Product crystallises. Preferred molar ratio of nitrate:bile acid is 1:2. - Desoxycholic acid (2.35 g.) and PETN (316 mg) were dissolved in 20 ml. of a 1:1 mixture of methanol and benzene with warming. The soln. was cooled to 0 deg.C and the crystals which separated were collected to give a PETN/desoxycholic acid complex with a ratio of 1:2. The mother liquors gave a mixture of inclusion compounds having a PETN/bile acid ratio of from 3:1 to 6:1.