LUPUS ERYTHEMATOSUS SKIN TEST COMPOSITION AND ITS PREPARATION

摘要

1,218,460. Nucleic acid composition. BARDHAMILTON CO. Inc. 25 Sept., 1968 [25 Oct., 1967], No. 45438/68. Heading C3H. [Also in Division A5] An aqueous composition for injection as a skin test for systemic lupus erythematosus comprises deoxyribonucleic acid (DNA) dissolved to give, for example, 0À05% to 0À3% DNA in an aqueous vehicle containing a physiologically acceptable buffer to maintain the pH at from 6À9 to 8 and 0À2% to 0À5% of an alkali metal chloride, the buffer and the alkali metal chloride together providing 0À36% to 0À7% solids in the composition. The DNA may be calf's thymus or other mammalian DNA or may be obtained from yeast or herring or salmon sperm, and may be sterilized before use by exposing it to ethylene oxide. The buffer may be phosphate buffer and the chloride may be sodium chloride. 0À4% phenol may be included as bactericide.