A procedure for the preparation of the salts of the gamma-lactama of the acid 6h, 7h-cis-7- (para-aminopenylacetamido) -3-aminomethyl-cef-3-em-4-carboxylic in the optically active or racemical form. (Machine-translation by Google Translate, not legally binding)

摘要

A process for the preparation of the 6h, 7h-cis-7- (para-aminophenylacetocid) -3-aminomethyl-cef-3-em-4-carboxylic acid gamma-lactam salts, in optically active or racemic form, general formula: ** (see formula) ** Wherein x represents a mineral or organic anion, characterized in that the gamma-lactam of 6h, 7h-cis-7-amino-3-aminomethyl-cef-3-em-4-carboxylic acid, optically active or racemic is condensed, with the para-nitrophenylacetic acid or with a functional derivative thereof, to form the gamma-lactam of 7 (para-nitrophenylacetamido) -3-aminomethyl-cef-3-em-4-carboxylic acid, this is reduced by catalytic hydrogenation in acidic or neutral medium to obtain the 6h, 7h-cis-7- (para-aminophenylacetamido) -3-aminomethyl-cef-3-em-4-carboxylic acid gamma-lactam in salified or free form, and this is salified last with an acid. (Machine-translation by Google Translate, not legally binding)