3,3,5-trimethylcyclohexylamine derivs - with hypertensive/hypotensive

摘要

Title derivs. of formula (I): (where R1 is H or 1-4C opt. satd. alkyl; and R2 is 1-6C opt. satd. alkyl, cycloalkyl with 5-7 ring C-atoms and opt. substd. by methyl gps., or phenylalkyl in which the alkyl has 1-3 chain atoms and is opt. substd. by 1-3 1-4C atoms and the phenyl is opt. substd. by 1-3 1-4C alkyl or alkoxy gps. or Cl atoms; or NR1R2 is satd. heterocyclyl with 5-7 ring members of which one can be an O- or substd. N-atom) adn their salts with acids have hypertensive activity (at low dosage, duration 10-30 mins.) and hypotensive activity (at high dosage, duration 1-3 mins.). Corresponding quaternary cpds. of formula (II): (where R3 is 1-4C alkyl and Anion is the residue of an inorganic acid) have only hypotensive activity (which activity is not attributable to ganglionic blockade). Processes for preparing (I) and (II) are described and claimed in the specification.