CLOSED SYSTEM GENERATION AND CONTAINERIZATION OF RADIOISOTOPES FOR ELUTING A DAUGHTER RADIOISOTOPE FROM A PARENT RADIOISOTOPE

摘要

Apparatus for eluting a sterile daughter radioisotope from a parent radioisotope and containerizing the resultant eluate in an evacuated container having a rubber stopper, providing for delivery of a sterile pyrogen-free eluant from a sealed supply through a sterile charge of the parent radioisotope sealed in a shielded generator and thence to a tubular needle adapted to be pierced through the stopper of the evacuated container for suctioning the eluant from the sealed eluant supply into the generator and for suctioning the resultant eluate into the container. The needle is applied to a fitting on a plunger adapted to be pushed down to pierce the needle through the stopper. Eluate is delivered from the generator to the fitting for flow through the needle via an eluate conduit having a flexible tubing portion permitting movement of the plunger and the fitting, with an arrangement whereby the plunger, when retracted, pinches the flexible tubing portion closed, the flexible tubing portion being automatically released when the plunger is driven downward to open the flexible tubing portion for flow therethrough of the eluate under suction induced by the piercing of the needle through the stopper into the evacuated container.