A process for preserving material suscetivel of danificacao's non contamination with microorganisms and to prepare for the new salts and composition of salts of dibenziodolio and dibenzobiomolio him available

摘要

The invention comprises: (i) the hydroxide, (ii) the carbonate, (iii) the propionate, (iv) the butyrate, (v) the cyclopropanecarboxylate, (vi) the tartrate, (vii) the citrate, (viii) the malonate, (ix) the methanesulphonate and (x) the isethionate of the dibenziodolium cation: PICT:1013571/C2/1 They may be prepared by conventional methods.ALSO:Materials susceptible to damage by contaminating micro-organisms, in particular vaccines, are preserved by adding thereto small quantities (eg. 1 part to 1000-100000 parts by weight) of a salt of the dibenziodolium or dibenzbromolium cation with an acceptable organic or inorganic anion, the said cations having the formulae FORM:1013571/A5-A6/1 (I) FORM:1013571/A5-A6/2 (II) Specified vaccines are those containing living bacterial spores eg. those of Bacillus anthracis and killed clostrident vaccines eg. those containing Clostridium botulinum, C. chauvoei, C. oedematiens, C. perfringens (types B, C and D), C. Septicum and C. tetani. The inventions further comprises pharmaceutical bacteriostatic compositions for topical use comprising a carrier and a dibenziodolium or dibenzbromolium salt e.g. in the form of a lotion, cream, jelly, ointment, tincture or eardrops.