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A process for the preparation of 3-cyclopentyl ether of 7α-methyl-17α-ethinyl-estradiol.
A process for the preparation of 3-cyclopentyl ether of 7α-methyl-17α-ethinyl-estradiol.
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机译:一种7α-甲基-17α-乙炔基-雌二醇的3-环戊基醚的制备方法。
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摘要
7 Alpha-methyl-17 alpha-ethinyl-oestradiol-3-cyclopentyl ether, oestrogenic, uterotropic, fertility regulator. Title cpds. of formula may be prepd. by reacting 3-cyclopentyloxy-7alpha-methyl-17-oxo-DELTA1,3,5(10)-oestratriene with a metal acetylide (e.g. Na, K or Li) or an acetylenic Grignard reagent, or by etherifying 7alpha-methyl-ethinyl-oestradiol with cyclopentanol or its reactive deriv. The cpd. hs oestrogenic, uterotropic and blastocyte implantation inhibiting activity.
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