1327946 17# - Hydroxy - 7 - methyl - 1,2- methylene - #SP4/SP - androsten - 3 - one and acylates thereof SCHERING AG 7 Dec 1970 [6 Dec 1969] 58022/70 Heading C2U The novel title steroids are prepared by dechlorination and ring opening of 4-chloro-17#- (hydroxy or acyloxy)-1,2; 6,7-dimethylene- #SP4/SP-androsten-3-ones using zinc and acetic acid, or by reaction of 17#-(hydroxy or acyloxy)-1,2- methylene - #SP4,6/SP - androstadien - 3 - ones with a methyl magnesium halide in the presence of cuprous chloride with subsequent isomerization of any 7-methyl-#SP5/SP-steroid formed by acid treatment. Resulting 17-acylates may be hydrolysed and the 17-ol acylated. The novel steroids are stated to be anabolic agents with a favourable anabolic-androgenic ratio, and they may be made up into pharmaceutical compositions with suitable carriers.
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