Intermediates for anti-convulsive benzodiazepine prodn. - prepd. by reacting 5-chloro-2-aminobenzophenones with haloacetonitriles

摘要

Inters. for the prepn. of 7-Cl-2,3-dihydro-1-Me- and 7-Cl-2,3-dihydro-5-Ph-1H-1,4-benzodiazepines, which have anti-convulsive, muscle-relaxing and tranquillising activity, are of formula (I): (where X is -CH2CN and R is H or Me) and are prepd. by reacting precursors (II) having formula (I where X = H) with ClCH2CN, BrCH2CN or ICH2CN. ClCH2CN acts as reactant and solvent. Pref. reaction with ClCH2CN is effected in the presence of an alkali metal bromide or iodide, esp. KI.