Alpha-acetyl cardenolide tridigitoxosides prodn - - by reacting tridigitoxosides with dialkylacetamide acetals and hydr

摘要

alpha-Acetyl derivs. of cardenolide tridigitoxosides are produced by reacting cardenolide tridigitoxosides with dialkylacetamide dialkyl acetals (pref. dimethylacetamide dimethyl acetal) in an inert solvent and subsequently hydrolysing in acidic medium. Acylation takes place selectively in the 3-posn. of the terminal digitoxose residue and almost pure products are obtained in high yields. The products (e.g. alpha-acetyldigoxin, alpha-acetyldigitoxin) have cardioactivity.