17-cyclo octenyloxy steroids - having androgenic and anabolic activity

摘要

17-Cyclo-octenyloxy steroids of general formula (I): R1 = O or Ac = acetyl; R2 = H or Methyl; R3 = methyl or ethyl. Ring A has opt. one double bond at 1(2)-, 4(5)- or 5(10); or two double bonds at 1(2) and 4(5) positions; = beta or alpha-configuration. (I) have androgenic- and anabolic activity and may be used as male hormones or "building" agents. (I) have twice the activity of e.g. methyltestorsterone and a 4 times higher androgenic activity and 2-3 times higher inyogenic activity than the corresp. cyclopentenyl steroids. The activity of (I) is short-lived so that no continuing blocking action on pituitary secretion occurs.