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3-Pyrrolidylidene tricyclic cpds. - with antitremor activity and a favourable antitremor/antisalivation activity
3-Pyrrolidylidene tricyclic cpds. - with antitremor activity and a favourable antitremor/antisalivation activity
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机译:3-吡咯亚烷基三环cpds。 -具有抗震颤活性和良好的抗震颤/抗流涎活性
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摘要
Cpds. of formula (I): (where A is O or ethylene; X1 and X2 are H or halogen; R1 is H or lower alkyl; R2 is lower alkylene; and R3 is lower alkyl or aryl opt. subst. by 1-3 lower alkoxy groups) and their acid addition salts which are useful in the treatment of Parkinsonism, are prepared by reacting compounds of formula (II) or their salts with carboxylic acids of the formula R3COOH or their reactive functional derivatives.
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机译:Cpds。式(I)的通式:(其中A为O或乙烯; X 1和X 2为H或卤素; R 1为H或低级烷基; R 2为低级亚烷基;且R 3为低级烷基或芳基,优选低1-3个可通过使式(II)的化合物或其盐与式R 3 COOH的羧酸或其反应性功能性衍生物反应来制备可用于治疗帕金森氏症的烷氧基)及其酸加成盐。
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