ALKYL DERIVATIVES OF 3-AMINOMETHYL SPIRO -DIBENZO-A-D- CYCLOHEPTADI-OR TRI-ENE 5-2- DIOXOLANE 1,3- THEIR METHOD OF PREPARATION AND THEIR THERAPEUTIC APPLICATION

摘要

1346163 Alkyl derivatives of 4SP1/SP-aminomethylspino[dibenzo(a-d)cycloheptadi- (or tri)- ene 5 : 2SP1/SP - dioxolane(1SP1/SP,3SP1/SP)] DELALANDE SA 3 Jan 1973 [1 Dec 1972 5 Dec 1972] 311/73 Addition to 1295815 Heading C2 Alkyl derivatives of 4SP1/SP-uminomethylspino- [dibenzo(a-d)cycloheptadi- (or tri)ene - 5 : 2SP1/SP- dioxolane(1SP1/SP,3SP1/SP)] of formula in which Z represents a -CH 2 -CH 2 - or -CH=CH- bridge and R represents an alkyl group having from 1 to 4 carbon atoms and their maleate salts are claimed per se. The compounds may be prepared by condensing in a benzene medium 4SP1/SP-bromomethyl spino[dibenzo(a-d)cycloheptadi - (or tri)ene - 5 : 2SP1 /SP- dioxolane- (1SP1/SP,3SP1/SP)] of formula with a primary amine of formula R-NH 2 . The compounds have therapeutic application.