3{40 -KETO-2{40 ,3{40 -SECO-1{40 -(2{40 )-YNE STEROIDAL DERIVATIVES, METHODS FOR THEIR MANUFACTURE, AND COMPOUNDS PRODUCED THEREBY

摘要

Described herein are novel 3'-keto-2',3'-seco-1'(2')-yne steroidal structures and processes for their preparation and, in particular, the preferred embodiment thereof, i.e., 5-keto-4,5-seco-3-ynes of the estrane, androstane, and pregnane series having physiological activity and being particularly useful as intermediates in preparing pharmacologically active 6- and/or 10-substituted steroids.