New 6alphaalpha - alkyl (c1-c4) - 3 - (C1 - C4) - alkoxy 2,3,5,6,6alpha, 8 - hexahidro 2,3,5,6,6alpha 8.9, respectively.9alphabeta octahidrociclopenta - F - L benzopiran 7 1H - trees and their Derivatives Esterified and etherified substituted at position 3Appropriate as Intermediates in the total synthesis of steroids, devoid of Therapeutic Action and Procedure for obtaining them

摘要

1431820 Benzopyran derivatives SCHERING AG 7 June 1973 [8 June 1972 (2)] 27236/73 Heading C2C The invention comprises compounds of general Formula II: in which R 1 and R 3 are each C 1 -C 4 alkyl; n is 1 or 2; -A-B- is wherein in the grouping the 9a-hydrogen is trans to the 6a substituent; X is a free, esterified or etherified hydroxyl group and Y is hydrogen, or X and Y together are an oxygen atom; and W is in which V is halogen, Z is a ketalized carbonyl group or a free, esterified or etherified hydroxymethylene group, R 4 and R 5 are C 1 -C 4 alkyl, and R 6 is alkyl, aryl or aralkyl. They may be prepared by cyclization of a compound of Formula IV: in the presence of an acidic catalyst. Any keto group represented by X and Y together with the adjacent carbon atom in the resulting compound may be reduced to form a free hydroxyl group and/or the double bond in the grouping represented by -A-B- may be hydrogenated and/or any free hydroxyl group represented by X may be esterified or etherified.