Product for use in the human body dentifricio locao toilet toilet preparation and COSMETICA handkerchief of cleaning the toothpicks preparation you 'd want to eat chewing gum preparation drinkable and pharmaCeutica process of giving feeling of cold smoke cigarette and carboxamide aliciclica

摘要

A compsn. which produces the sensation of cold when applied to the skin or mucous membranes contains a cpd. which stimulates the cold receptors of the nervous system of surface tissues in the human body, of formula (I): (where n = 0-6; R is 1-6C alkyl; x = 1-4; X is OH, COOH, COOR1 or CONR1R2; R1 is 2-4C hydroxyalkyl; R2 is H or 1-10C alkyl and R3 is H, 1-10C alkyl, 1-10C hydroxyalkyl or =8C alkanoyloxyalkyl, or R2 is H and R3 is =8C cycloalkyl, phenyl, or phenyl substd. by alkyl, OH or MeO (total =10C), or R2 and R3 together form a =8C alkylene gp. opt. interrupted by an O atom; with the proviso that at least one R gp. is in the 1 or 2 posn. relative to the X gp. when X = OH or in the 1,2 or 3 posn. when X = COOH, COOR1 or CONR2R3, and that the R gp(s). and the carbocyclic ring contain a total of 8-14C atoms). Cpds. (I) can be used in toilet and cosmetic articles, foodstuffs, tobacco prodts. and pharmaceutical compsns. The cpds. have a physiological cooling effect similar to menthol (sometimes superior) without having the strong peppermint aroma of menthol.