A process for preparing N-diethylaminoethyl-2-methoxy-4-amino-5-chlorobenzamide and acid addition salts or quaternary ammonium salts thereof.

摘要

1395131 N - [2 - (N,N - diethylamino)ethyl]- 2 - methoxy - 4 - amino - 5 - chlorobenzamide SOC D'ETUDES SCIENTIFIQUES ET INDUSTRIELLES DE L'ILE-DE-FRANCE 13 June 1973 [20 June 1972] 28203/73 Heading C2C N - [2 - (NSP1/SP,NSP1/SP - diethylamino)ethyl] - 2- methoxy - 4 - amino - 5 - chlorobenzamide is prepared by reacting a C 1-3 alkyl 2-methoxy-4- acetamido-5-chlorobenzoate with ethanolamine, reacting the resulting novel N-(2-hydroxyethyl)- 2 - methoxy - 4 - acetamido - 5 - chlorobenzamide with thionyl chloride, followed by alkaline hydrolysis, and reacting the resulting novel N - (2 - chloroethyl) - 2 - methoxy - 4 - amino - 5- chlorobenzamide with diethylamine; and may subsequently be converted to its pharmaceutically acceptable mineral or organic acid addition salts or quaternary ammonium salts.