FOERFARANDE Før FRAMSTAELLNING audio ANALGETISKT VERKANDE RACE MISKA the OR DIASTEREOMERA OCH optically active 2-TETRAHYDROFURFURYL- (1R / S, 5R / S, 9R / S) -2'-hydroxy-5,9-dimethyl-6,7-OCH BENSOMORFANER deras SYRAADDITIONSSALTER

摘要

Novel 2-tetrahydrofurfuryl-6-7-benzomorphans of the accompanying formula I, in which R1 denotes methyl, ethyl or propyl; R2 denotes hydrogen, methyl or ethyl; R3 denotes hydrogen or methyl; and R4 denotes hydrogen, alkyl having 1 to 4 carbon atoms or acyl having 2 to 5 carbon atoms, are prepared by introducing the tetrahydrofurfuryl radical into appropriately substituted norbenzomorphans by the methods of N-alkylation. The resulting bases of the formula I can then be converted into their acid addition salts. The compounds of the formula I and their acid addition salts are distinguished by a therapeutically utilisable action on the central nervous system. Particularly to be emphasised is their analgesic action, which frequently exceeds that of morphine, without exhibiting the undesired side effects of morphine, e.g. the addictive action. IMAGE