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A PROCESS FOR THE SYNTHESIS OF 2,2-DISUBSTITUTED-3,4-DIPHENYLCHROMANS

机译:2,2-二取代的3,4-二苯基氯的合成方法

摘要

We claim:   1. A process for the preparation of the compounds of the formula 2 or 3 given in Fig. 2, wherein R is lower alkyl, B" and R"" may be hydroxy, chloro, fluoro, trifluoromethyl, lower alkyl, lower alkoxy or tertiary amino lower alkoxy groups, comprising reacting compound of the formula 1of Fig, 2, wherein R, R" and R"" are as defined above, with B- chloroethyl pyrroli-dine in a ketonic solvent in presence of an acid binding agent to obtain a compound of the formula 2 shown in Fig, 2; if desired isomerising the compound of formula 2 shown in Fig. 2, to a compound of formula 3 shown in Fig. 2, with a strong base in an aprotic solvent.
机译:我们要求保护:1.一种制备图2中给出的式2或3的化合物的方法,其中R是低级烷基,B”和R””可以是羟基,氯,氟,三氟甲基,低级烷基,低级烷氧基或叔氨基低级烷氧基,包括在酸存在下在酮溶剂中使图2的式1化合物与B-氯乙基吡咯烷反应,其中R,R“和R”“如上定义结合剂获得图2所示的式2化合物;如果需要的话,在非质子溶剂中用强碱将图2所示的式2化合物异构化为图2所示的式3化合物。

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