PROCESS FOR PRODUCING ATTENUTED LIVE MEASLES VIRUS VACCINE.

摘要

Process for the production of a measles vaccine of live attenuated measles virus which comprises propagating and growing the Schwarz strain of measles virus, which has been obtained by the adaptation of native measles virus so that it is capable of growing in living non-human cell tissue or in media containing said living non-human cells and by attenuation of the adapted  virus  by  multiple  serial  passage through  a cells, at a temperature below 35"C. but at a temperature higher than that at which propagation of the virus ceases, in a culture medium which comprises live animal cells, and separating the cell and debris material from the culture medium by conventional means such as decantation, centrifugation or filtration.