Process for preparing antibiotic F.I. 1762, its acid addition salts or its aglycone, characterized in that Streptomyces F-l- H62 or a mutant thereof is cultured, under aerobic conditions, in a liquid nutrient medium containing a source of assimilable carbon and nitrogen, and mineral salts, at a temperature of from 25 io 37C, for a period of from 3 to 7 days, the pH of the medium being initially from 6.5 to 7.0 and finally from 7.5 to 8.0 and the formed antibiotic F.I. 1762 is extracted from the culture broth by an organic solvent and isolated as such by crystallization or transformed into its acid addition salts by treatment with an organic or inorganic acid or into its aglycone by hydrolysis with a dilute mineral acid.
展开▼