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PROCESS FOR THE PREPARATION OF A NEW ANTIBIOTIC F. I. 1762

机译:新的抗生素F.I.1762的制备过程

摘要

Process for preparing antibiotic F.I. 1762, its acid addition salts or its aglycone, characterized in that Streptomyces F-l- H62 or a mutant thereof is cultured, under aerobic conditions, in a liquid nutrient medium containing a source of assimilable carbon and nitrogen, and mineral salts, at a temperature of from 25 io 37C, for a period of from 3 to 7 days, the pH of the medium being initially from 6.5 to 7.0 and finally from 7.5 to 8.0 and the formed antibiotic F.I. 1762 is extracted from the culture broth by an organic solvent and isolated as such by crystallization or transformed into its acid addition salts by treatment with an organic or inorganic acid or into its aglycone by hydrolysis with a dilute mineral acid.
机译:制备抗生素F.I.的方法1762,其酸加成盐或其糖苷配基,其特征在于链霉菌Fl-H62或其突变体在有氧条件下,在含有可吸收的碳和氮源以及矿物盐的液体营养培养基中,在80℃的温度下培养。从25到37摄氏度,持续3到7天,培养基的pH最初是6.5到7.0,最后是7.5到8.0,形成的抗生素FI用有机溶剂从培养液中提取1762,并通过结晶将其原样分离,或通过用有机或无机酸处理而转化成其酸加成盐,或通过用稀无机酸水解而转化成其糖苷配基。

著录项

  • 公开/公告号IN90770B

    专利类型

  • 公开/公告日1975-02-08

    原文格式PDF

  • 申请/专利权人

    申请/专利号IN90770

  • 发明设计人

    申请日1963-11-11

  • 分类号

  • 国家 IN

  • 入库时间 2022-08-23 04:38:21

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