process for the preparation of non immunogenic polypeptides, methods for the preparation of medicines, which be immunogenic polypeptides and the products thus formed.

摘要

A method for suppressing the immunogenic action of a biocatalyst which has a large number of peptide linkages, with at least partial retention of its physiological activity, entails attaching polymers to the biocatalyst; the biocatalyst is attached to a virtually linear polyalkyl or polyalkoxy polymer via at least one terminal carbon atom thereof; the polyalkyl or polyalkoxy polymer is unsubstituted or substituted by an alkoxy or alkyl group containing fewer than 5 C atoms.