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Ni and n n substituted phenobarbitone barbitone and - 5 5 diphenyl hydantoin derivatives
Ni and n n substituted phenobarbitone barbitone and - 5 5 diphenyl hydantoin derivatives
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机译:Ni和n n取代的苯巴比妥巴比妥酮和-5 5二苯乙内酰脲衍生物
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摘要
Compounds (I) are new and useful as hypnotics and anti-convulsants with minimal side effects: (where Z is CO or a single bond, X and X' are both Ph when Z is a bond or X and X' are both Et or X is Et and X' is Ph when Z is CO; Y and Y' are both 1-12C-alkoxymethyl, benzyloxymethyl, or acyloxymethyl, or Y is H and Y' is 1-12C alkoxymethyl, benzyloxymethyl or carboxylic acyloxymethyl when Z is a single bond). Prepared by alkoxyalkylation, or aralkoxyalkylation of the appropriate N,N'-unsubstd. compounds or acylation of the corresponding hydroxymethylated compounds. Preferred compds. are (I), X=Ph, X'=Et, Z=CO and Y=Y'=MeOCH2 or MeOCOCH2; X=X'=Et, Z=CO and Y=Y'=MeOCH2 or MeOCOCH2; and X=X'=Ph, Z=single bond, Y'=H and Y=MeOCH2 or MeOCOCH2, and Y=Y'=MeOCH2 and MeOCOCH2.
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