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process for the preparation of a drug with anti ulcusactiviteit del formed cure with such activity and working method for the preparation of medicinal compounds.

机译:具有这种活性的抗溃疡活性药物的制备方法和制备药物的工作方法。

摘要

Triazine derivs. of formula (I): (where X and Y are halogen, provided that X, Y is other than 3,4-Cl2), e.g. 2,4-diamino-6-(2,5-dichlorophenyl)-1,3,5-triazine, and their non-toxic acid addition salts are new cpds. (I) have high antipeptic activity against ulcers, coupled with low toxicity. (I) may be obtained by (a) reacting a corresponding dihalobenzonitrile with dicyandiamide or (b) reacting a dihalobenzoic acid or functional deriv. thereof with biguanide. (I) may also be obtained e.g. by reacting a 2,4-dichloro-6-(dihalophenyl)-1,3,5-triazine with ammonia.
机译:三嗪衍生。式(I)的通式:(其中X和Y是卤素,条件是X,Y不是3,4-Cl2)。 2,4-二氨基-6-(2,5-二氯苯基)-1,3,5-三嗪及其无毒酸加成盐是新的cpds。 (一)对溃疡有很高的抗菌活性,同时毒性低。 (I)可通过(a)使相应的二卤代苄腈与双氰胺反应或(b)使二卤代苯甲酸或官能衍生物反应而获得。其中与双胍。 (I)也可以例如通过使2,4-二氯-6-(二卤代苯基)-1,3,5-三嗪与氨反应

著录项

  • 公开/公告号NL7501575A

    专利类型

  • 公开/公告日1975-08-20

    原文格式PDF

  • 申请/专利权人 NIPPON SHINYAKU CO. LTD. TE KYOTO JAPAN.;

    申请/专利号NL19750001575

  • 发明设计人

    申请日1975-02-11

  • 分类号A61K31/53;C07D251/18;

  • 国家 NL

  • 入库时间 2022-08-23 04:35:36

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