A method for producing new compounds of 1.2 methylene 17 alpha - aciloxi (or improved hydroxy) - 3 beta, 10 alpha - steroids of the pregnan series. (Machine-translation by Google Translate, not legally binding)

摘要

A method of producing novel 1,2-methylene-17α-acyloxy (or improved hydroxy) -9β, 10α-steroids compounds of the pregnane series, of the general formula **(See formula)** formula in which X and X together represent a double-bonded oxygen atom, or X is a hydrogen atom and X is a hydroxyl group or an esterified hydroxyl group, R3 is a 3-keto-4-dehydro-group., a 3-keto-4,6-bisdeshydro- group, a 3-OR'-3,5-bis-dehydro- group or a 3-OR'-4,6-bisdeshidro- group, where OR'is a hydroxyl group etherified or esterified; R6 is a hydrogen atom, a chlorine atom, a fluorine atom, a 6,6-difluor- group, a 6.6 group, -dichloro- or a methyl group, whereas, if R6 is a hydrogen atom, R7 is a 7-methylene group-, while if R7 is a 6,7-methylene group-, R6 is a hydrogen atom, a chlorine atom or a fluorine atom, R3 is a 3-keto-4 group -dehydro-, R17 is an esterified hydroxyl group having 1 to 5 carbon atoms or an esterified hydroxyl group having 1 to 8 carbon atoms, R21 is a hydrogen atom, a fluorine atom, a hydroxyl group or an esterified hydroxyl group, and R13 is a methyl group or an ethyl group, characterized by producing the compounds by subjecting a compound of the formula **(See formula)** wherein R13, R17, R21, X and Y have the meanings given above, with the exception that the combination R17 and/or R21 is an esterified hydroxyl group, and X and Y are together a double-bonded oxygen atom, R6 is a hydrogen atom, a chlorine atom or a fluorine atom, to a methylation reaction, which produces a compound of the formula **(See formula)** where R6, R13, R17, R21, X and Y have the above meanings. (Machine-translation by Google Translate, not legally binding)