BIS-N-QUINAZOLOONE AND - BONZOTRIAZINE DERIVATIVES BIS-N-QUINAZOLOONE AND - BONZOTRIAZINE DERIVATIVES

摘要

1429339 Bis - N - heterocyclic ketones HOECHST AG 14 June 1973 [15 June 1972 (4)] 28371/73 Heading C2C Novel compounds (I), (II) and (III) where R represents an alkyl, alkenyl or alkynyl group containing up to 6 carbon atoms; an unsubstituted or substituted phenyl group in which the substituents may be one or more groups selected from hydroxy, methoxy, amino, alkylamino, methyl, trifluoromethyl, nitro, cyano, carboxyl, and sulphonic acid groups, and fluorine, chlorine, and bromine atoms, an aralkyl group in which the aryl nucleus may be substituted with one or more of the substituents described above; or a heterocyclic group, for example, nitrofuryl group; R 1 and RSP1/SP 1 which may be the same or different, each represents a hydroxy, methoxy, amino, alkylamino, methyl, trifluoromethyl, nitro, cyano, carboxyl or sulphonic acid group or a hydrogen, fluorine, chlorine or bromine atom, and n is the integer 1 or 2, are made by treating compounds (IV) with a diazotizing agent and/or with RCHO. N - [2 - (5 - nitrofuran - 2 - yl) - 1,2,3,4 - tetrahydroquinazolin - 4 - one - 3 - yl] - 5 - nitro - 2- amino-benzamide is also prepared. Pharmaceutical preparations having activity against gram-positive bacteria contain (I), (II) and/or (III) as active ingredient.