Dicarbonyl compds and 21-alkanoyl-pregna- - 4-ene-3, 20-diones prepn

摘要

Dicarbonyl compds and 21-alkanoyl-pregna-4-ene-3,20-diones prepn. Compds (I): (where R' is R1CO or CM; R" is R2CO R3OCO or CM; R1R2 and R4-R8 are H or organic residues; R3 is an organic residue; one or more of R1R2 and R4-R8 may be linked to form a cyclic residue 4C and n, and R2 are 0, 1 or 2) are prepd. simply and in good yield by treating a compd. (II) with a stony base and opt. a thiophilic agent esp. a trivalent P-compd. Prefd., products are steroids and esp. compd (III) (which are anti-inflammatory agents) and their 1,2-satd. nor derivs and DELTA, 135 (10)-triene steroids carrying a (III) 3-free, etherified or esterified OH and where R1 is an opt substd hydrocarbon; R2 is H, OH or OAcyl; R3 is H, OH, OAcyl or Me; R2 + R3 may be a bond or alkylene- or cycloalkylene-dioxy; R4 is H, Cl, OH or OAcyl; R4 + R5 may be O; R6 is Ha Hal; R4 + R6 may be a hond or epoxy; R7 is H, Me or Ha and R8 is H or when 1,2 is present H or Cl.