2-(aryl-carbamoyl)-cyclohexane-1,3-diones - prepd from iso(thio)cyanate and di-hydro-resorcinol alkali salt

摘要

Cpds. of formula (I): (where X is O or S; A is naphthyl or R1 and R2 are each H, Cl, Br, I, F, lower alkyl, NO2, acetyl, -N(R)2, CO2R or OR; R is lower alkyl; R3 is H, monocyclic aryl or monocyclic O- or S-heterocycle, aryls and heterocycles being opt. substd. by halogen, lower alkyl, lower alkoxy or NO2; R4 is as R3 excluding H; R3 and R4 are the same when R3 is not H) are prepd. by the reaction of A-N=C=X on (II) (where M is alakli metal). (I) show antibacterial props. in concns. of 0.2-10 mug/ml.