1-trans-cinnamyl-4-diphenylmethyl - piperazine-antihistamine by reduction of 1-trans-cinnamoyl deriv

摘要

In the title process a mixt. of piperazine hexahydrate and the dihydrochloride is reacted with diphenylmethylchloride to give diphenylmethylpiperazine, which is acylated with trans-cinnamoyl halide and the CO group reduced to CH2. Prod. is obtd. in good yield.