Isocyanato-benzoxazoles-benzothiazoles and benimidazoles - as anthelmintics and antimicrobials

摘要

Cpds (I) (where SCN occupies positions 4,5,6 or 7, R1 is H, 1-17C alkyl or alkenyl opt. substd. by CN, halogen, OH, Oalkyl, acyl, Salkyl or dialkylamino contg. up to a total of 6C, a mono-, bi- or tricyclic cycloalkyl or cycloalkenyl contg. 3-10 intracyclic C atoms and opt. substd. by alkyl gps. the cyclic radical opt. being linked to Y or to the heterocyclic residue by CH2-, R2 is H, halogen or 1-4C-alkyl, -Oalkyl or -acyl, X is O, S or NR3, R3 is H, 1-5C-alkyl or -alkenyl, Ph, PhCH2, dimethyl- or diethyl-amino-(2-5C-alkyl), 2-5C-alkoxycarbonyl or acyl or polyhydroxy alkyl (ose or oside), Y is O, S, SO SO2 or N-R4, n is 0 or 1, R4 is H, 1-5C-alkyl or -alkenyl, or together with the N-atom and R1 is a 4-, 5- or 6-membered heterocyclic ring opt. contg. a further O, S or NR5 residue and R5 is H, Me or Et) are prepd. by various methods from the corresponding amino cpd. or by cyclising an isothiocyanato-2-acylamino phenol, which cpd. also forms part of the invention.