Amino and amido phenyl tetrahydro pyrans - anti-inflammatories for treat-ment of rheumatism arthroses lumbago and feverish conditions

摘要

Title cpds. are of formula (I): (where Hal = halogen, X = O or S, Z = -Y-CONR1R2 or -Y-CH2NR1R3, Y -(CH2)n- or -CHR-, n = 0 or 1, R = alkyl (1-5C), R1 and R3 = H or alkyl, (1-5C), R2 = H, alkyl or alkoxy (1-5C) or R1-R2, or R1-R3 = alkylene (4 or 5C) or -CH2CH2OCH2CH2-). They may be prepd. by condensation of an amine with pyranyl phenyl acid to give (I), Z = -Y-CO-NR1R2, and this may be reduced to give (I) Z = Y-CH2NR1-R2.