4-(1'-ALKYL-5'-NITROIMIDAZOLYL-2'-METHYLENE-IMINO)-TETRAHYDRO-1,4-THIA ZINE 1,1-DIOXIDES OF THE FORMULA IN WHICH R1 is hydrogen, methyl, ethyl, or 2-hydroxy-ethyl and R2 is hydrogen, methyl, ethyl or methoxymethyl, are prepared by reaction of 1-alkyl-5-nitroimidazolyl-2-aldehyde or a functional derivative thereof with 4-amino-tetrahydro-1,4-thiazine 1,1-dioxide. The products of the invention are suitable for the treatment of protozoal diseases.
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