Method of treating angina pectoris, coronary insufficiency, and preventing myocardial infarction

摘要

A method of treating angina pectoris (i.e., suppressing the incidence of angina and relieving the painful symptoms of anginal attacks, treating coronary insufficiency and suppressing the incidence of myocardial infarction in living beings by increasing coronary blood flow by blocking the sympathetic nervous system by administration of a post-ganglionic sympathetic blocking agent. Bretylium tosylate, bethanidine and guanethidine are among the drugs known to have post-ganglionic sympathetic blocking properties. The drug is preferably administered prophylactically in angina-prone patients in advance of an anginal episode but it may also be given to shorten the duration and relieve the pain of an anginal attack in progress. In patients with signs and symptoms of acute coronary insufficiency and acute myocardial infarction, the prompt induction of sympathetic blockade will prevent and/or minimize the death of heart muscle (myocardial infarction).