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Process for the manufacture of 2 - imino - 3 - (2 - chlorine - 2 - phenyl ethyl) tiazolidina (ICPT) and its salts of adicao acid, and for the manufacture of tetramisol and its salts of acid adicao
Process for the manufacture of 2 - imino - 3 - (2 - chlorine - 2 - phenyl ethyl) tiazolidina (ICPT) and its salts of adicao acid, and for the manufacture of tetramisol and its salts of acid adicao
Process for the manufacture of 2-imino-3-(2-chloro-2-phenylethyl)thiazolidine (known intermediate in manufacture of the anthelmintic agent tetramisole) by reacting 2-imino-3-(2-hydroxy-2-phenylethyl)thiazolidine with chlorosulphonic acid and either aqueous hydrochloric acid or water. Preferred procedure involves use of chlorosulphonic acid and concentrated hydrochloric acid.
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