FOERFARANDE Før FRAMSTAELLNING audio FARMAKOLOGISKT VAERDEFULLA BENS-1,2-ISOXAZOLFOERENINGAR

摘要

The compounds correspond to the formula: IMAGE In this formula, R1 and R2 denote hydrogen, alkyl, alkoxy, aralkoxy, halogen, trifluoromethyl, or together denote alkylenedioxy, Alk denotes alkylene and A denotes a group -NR3R4, in which R3 and R4 denote alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl or, with the nitrogen atom, together form a 5- to 7-membered nitrogen-containing heterocycle which can additionally contain oxygen or sulphur as heteroatoms. They are prepared by cyclisation, preferably by means of a base or of an acid, of a corresponding 1-(2-nitrophenyl)-1-(A-Alk)alkan-2-one. The compounds and their salts exhibit a variety of pharmacological actions, inter alia a depressant action on the central nervous system and an inhibitory action on blood platelet agglutination.