process for the production of new n - (heteroaryl methyl) - 6.14 - endoatheno - 7alfa - hydroxyalkyl - tetrahydro - nororipavinen and thebainen

摘要

Compounds of the formula WHEREIN R1 is hydrogen, methyl or acetyl, R2 is hydrogen or methyl, R3 is hydrogen, methyl, n-propyl, phenethyl or phenyl, R4 is hydrogen or methyl, Z is -CH=CH- or -CH2-CH2-, and Y is oxygen or sulfur, AND NON-TOXIC, PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF; THE COMPOUNDS AS WELL AS THEIR SALTS ARE USEFUL AS ANALGESICS AND ANTITUSSIVES.