METHOD FOR EFFECTING INCREASED BILE FLOW COMPRISING ORALLY ADMINISTERING CHOLERETIC MEDICAMENTS CONTAINING 1-PHENOXY-3-ALKOXY-PROPANOLS

摘要

Manufacturing procedure of medicinally active substances, for choleretic action drugs, active substances that are compounds with the general formula ** (See formula) ** wherein R is a low alkyl radical having 1 to 6 C atoms, and R 1 and R 2 may be a hydrogen atom, a methyl or trifluoromethyl residue or a methoxy or ethoxy residue or, respectively, a chlorine or of fluorine, said substances being, in particular, 3-butoxy-1-phenoxy-propanol- (2), 3-isopropoxy-1- (4'methoxyphenoxy) -propanol- (2) or 3-ethoxy-1- (3'-methylphenoxy) -propanol- (2), characterized in that a 3-alkoxy-1-chloropropanol (2) is reacted with the formula C1-CH2-CHOH-CH2OR, where R is a low alkyl radical with 1 to 6 C atoms, with a phenolate of the formula ** (See formula) ** wherein R1 and R2 can be a hydrogen atom, a methyl or trifluoromethyl moiety or a methoxy or ethoxy moiety or, respectively, a chlorine atom or a fluorine atom, and where Me is an alkali metal or the ammonium group, or why a 1-phenoxy-3-chloropropanol of the formula ** (See formula) ** it is transformed with an alcoholate of the formula MeOR, where R1, R2, Me and R have the indicated meanings. (Machine-translation by Google Translate, not legally binding)