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ANTI-INFLAMMATORY STEROIDS OF THE ANDROSTANE SERIES HAVING A HALO-SUBSTITUTED C{11 {14 C{11 {11 ALKOXY CARBONYL GROUP AT THE 17{62 {0 POSITION
ANTI-INFLAMMATORY STEROIDS OF THE ANDROSTANE SERIES HAVING A HALO-SUBSTITUTED C{11 {14 C{11 {11 ALKOXY CARBONYL GROUP AT THE 17{62 {0 POSITION
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机译:具有卤素取代的C {11 {14 C {11 {11在17 {62 {0位置的烷氧基羰基的)雄烷系列的抗炎性甾体
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摘要
The Specification describes compounds of the general formula WHEREIN X represents a hydrogen, chlorine or fluorine atom R1 represents a beta -hydroxy group, an oxo group or (when X is a chlorine atom) a beta -chlorine atom R2 represents a hydrogen atom, a methylene group or an alpha - or beta -methyl group R3 represents a hydrogen atom or C1-4alkyl or phenyl group R4 represents a methyl group substituted by at least one halogen atom an ethyl group substituted by at least one fluorine and/or iodine atom or a propyl group substituted by at least one halogen atom and represents a single or double bond. The Specification also describes processes for the preparation of compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I have good anti-inflammatory activity, particularly on topical application.
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