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5-FLUOROURACIL DERIVATIVES AND PROCESS OF PRODUCING 5-FLUOROURACIL AND DERIVATIVES THEREOF IN AQUEOUS SOLVENTS
5-FLUOROURACIL DERIVATIVES AND PROCESS OF PRODUCING 5-FLUOROURACIL AND DERIVATIVES THEREOF IN AQUEOUS SOLVENTS
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机译:5-氟尿嘧啶衍生物及其在水溶液中制备5-氟尿嘧啶及其衍生物的方法
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摘要
Direct fluorination of uracil and its derivatives, in the presence of an aqueous solvent, by fluorine gas to produce 5-fluorouracil and 5- fluorouracil derivatives is disclosed. Novel compounds produced by the reaction, such as 5,5-difluoro-6-hydroxy-5,6-dihydrouracil are also disclosed. The derivatives of 5-fluorouracil are useful as germicidal agents while 5-fluorouracil itself is a known cancer chemotherapy agent.
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