Cpds. of formula (I):- (where R1 is phenyl opt. substd. by 1 or 2 of halogen and/or lower alkyl or by a lower alkoxy gp. or by 1 or more CF3 gps., or is benzyl opt. substd. by halogen, or is cyclohexyl; R2 is H, lower alkyl (opt. substd. by 1 or 2 OH gps., a halogen, lower alkanoyloxy, alkoxy, vinyloxy, hydroxyalkoxy, phenyl, halophenyl, alkanoyl, halobenzoyl, nicotinoyl, COOH, alkoxycarbonyl, CONH2, CN, dialkylamino, 6-membered cyclic amino or aminocarbonyl, or ureido gp., a halogen and an OH gp., a halogen and an alkoxy gp., an OH and a phenyl gp., or an OH and a 6-membered cyclic amino gp.), lower alkenyl, lower haloalkenyl, lower alkynyl, lower alkoxycarbonyl or 2,3-epoxypropyl) are useful as anti-inflammatories, analgescis and CNS depressants, and also anti-ucler agents, antipyretics and antihistaminics. They can be prepd., e.g. by reacting the corresp. 2-R1NH-nicotinamide with XCOY (where X and Y are halogen, lower alkoxy, NH2 or imidazolyl).
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