Antiallergic benzo(4,5) cyclohepta(1,2-b)-thiophene derivs - prepd by reacting 4-(4-piperidinylidene)-4 H-benzo(4,5)6 cyclohepta(1,2-b)thiophen-9(10H)-one with a benz(hydr)yl halide

摘要

Process for preparing new thiophene derivs of formula (I) comprises reacting corresp. N-unsubstd. cpds. of formula (II) with benzyl halides (III), then opt. converting (I) to an acid addition salt. (R1 = H or a halo or lower alkoxy substit. at 6 or 7 posn.; R2 = H or halo; R3 = H, phenyl or halophenyl) (I) have histaminolytic, serotonin-antagonistic and anticholinergic activities so are useful in treating various sorts of allergies.