4,6-Bis (cyclic amino)-pyrazolo/3,4-d/pyrimidine derivs - prepd by e.g. reacting 4,6 -dihalo cpds with cyclic amines

摘要

amino)-pyrazolo/3,4-d/pyrimidine derivs. of formula (I): (where R1 is H, 1-3C alkyl, or phenyl opt. substd. by halogen or OCH; R3 is H, CH3, SCH3, benzylthio, methylsulphinyl or methylsulphonyl; and R4 and R6 are pierazino (ppt. substd. in the 4-posn. by acyl, carbamoyl, benzyl, 1-3C alkyl or 1-3C hydroxyalkyl), morpholino, thiamorpholino, 1-oxido-thiomorpholino 1,1-dioxido-thiomorpholino, hydrazino or alkenediamino, these residues opt. being C-substd. by 1 or 2 1-3C alkyl gps.), e.g. 4-(1-oxido-thiamorpholino)-6-piperazino-1H-pyrazolo/3,4-d/pyridim- idine, and their physiologically tolerable acid addition salts with inorganic or organic acids are new cpds. (I) have hypotensive and, esp. antithrombotic activity. (I) exhibit strong inhibition of thrombocyte aggregation and adhesiveness, this activity being accompanied by strong hypotensive activity when the cpds. carry a piperazino gp.; when the piperazino gp. is 4-substd. by acyl or lower alkyl, the cpds. have no influence on circulation and blood pressure.