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Compressible tablet formulations - contg branched fatty alcohols and/or fatty acid triglycerides and/or fatty alcohol esters as hydrophobic carrier materials

机译:可压缩片剂-含支链脂肪醇和/或脂肪酸甘油三酸酯和/或脂肪醇酯作为疏水性载体材料

摘要

Compressed dosage forms and tablet table mixts. contain (a) one or more pharmacological active substances (e.g. ergotamine tartrate, acetylsalicylic acid, aminophylline etc.) and (b) a carrier mixt. made up of (i) a hydrophobic ingredient melting at 34-40 degrees C which contains one or more physiologically tolerable hydrophobic substances of the type of branched primary fatty alcohols and/or monoacidic fatty acid triglycerides and/or fatty alcohol esters, opt. together with further hydrophobic physiologically tolerable substances, (ii) one or more physiologically tolerable hydrophilic polymers and (iii), opt. further physiologically tolerable adjuvants. The formulations contain a high proportion of low-melting hydrophobic carrier materials and are suitable for use as suppositories or vaginal tablets. The tablet-table mixts. are free-flowing, despite the low-melting and hydrophobic nature of the carrier material, and permit the producn. of suppositories and vaginal tablets, etc. by compression methods rather than the moulding methods used hitherto.
机译:压缩剂型和片剂表混合物。含有(a)一种或多种药理活性物质(例如酒石酸麦角胺,乙酰水杨酸,氨茶碱等)和(b)载体混合物。由(i)在34-40摄氏度下融化的疏水成分组成,其中包含一种或多种生理上可耐受的支链伯脂肪醇和/或单酸性脂肪酸甘油三酸酯和/或脂肪醇酯类型的疏水物质。与其他疏水的生理上可耐受的物质一起,(ii)一种或多种生理上可耐受的亲水性聚合物,以及(iii),选择。其他生理上可接受的佐剂。该制剂包含高比例的低熔点疏水性载体材料,并且适合用作栓剂或阴道片剂。平板电脑桌上的混音。尽管载体材料具有低熔点和疏水性,它们还是自由流动的,并允许生产。栓剂和阴道片剂等通过压缩方法而不是迄今为止使用的模制方法制成。

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