Subst vincanols and eburnamines - prepn by treating vincamone or eburnamonine with an organomagnesium

摘要

Substd. vincanols and eburnamines are prepd. by reacting vincamone or eburnamonine resp. with an equimolar amount of an organomagnesium cpd. contg. a satd. vinylic, acetylenic or aromatic group, which has been prepd, in an ether such as tetrahydrofuran or dioxan. In an example, methylvincanol is prepd. by reacting vincamone with methylmagnesium iodide. The products are useful for treating vascular and circulatory disorders.