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New acid esters, beta - aminocrotonic, their process of preparation and their application as inhibitors of metamorphoses
New acid esters, beta - aminocrotonic, their process of preparation and their application as inhibitors of metamorphoses
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机译:β-氨基巴豆酸新酸酯,其制备方法及其在变形酶抑制剂中的应用
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摘要
N-substituted -aminocrotonic acid esters of the formula ##STR1## in which R.sup.1 is hydrogen, or alkyl or alkenyl with up to 4 carbon atoms;PPR.sup.2 is straight-chain or branched alkyl or alkenyl with up to 9 carbon atoms, optionally interrupted by O or S, and optionally substituted by halogen, phenoxy, dimethylamino, cyclic alkyl or alkenyl with up to 8 carbon atoms which are optionally substituted by halogen, dimethylamino, or alkyl, alkoxy or alkylthio with up to 4 carbon atoms, phenyl which is optionally substituted by halogen, dimethylamino, phenoxy, or alkyl, alkenyl, acyl, alkoxy, alkenoxy or alkynoxy containing up to 4 carbon atoms, or a 5- or 6-membered heterocyclic ring containing at least one O, S or N hetero-atom and optionally substituted by halogen, alkyl or alkoxy containing up to 4 carbon atoms or R.sub.2 is further more cyclic alkyl or alkenyl with up to 8 carbon atoms optionally substituted by halogen, dimethylamino, or alkyl, alkoxy or alkylthio with up to 4 carbon atoms; phenyl optionally substituted by halogen, dimethylamino, phenoxy, or alkyl, alkenyl, acyl, alkoxy, alkenoxy or alkynoxy containing up to 4 carbon atoms; or a 5- or 6-membered heterocyclic ring containing at least one O, S or N heteroatom and optionally substituted by halogen, or alkyl or alkoxy containing up to 4 carbon atoms; orPPR.sup.1 and R.sup.2 together with the adjoining nitrogen atom form a heterocyclic structure optionally substituted by lower alkyl with 1-4 carbon atoms and optionally containing further heteroatoms in addition to nitrogen, andP PR.sup.3 is straight-chain or branched alkyl, alkenyl or alkynyl each with up to 10 carbon atoms, or cyclic alkyl or alkenyl with up to 8 carbon atoms, optionally substituted by halogen, alkoxy or alkyl-thio containing up to 4 carbon atoms, phenyl, 3,4-methylenedioxyphenyl, cyclic alkyl or alkenyl with up to 8 carbon atoms; phenyl optionally substituted by dioxymethylene or alkyl, alkenyl, alkynyl, alkoxy, alkenoxy, alkynoxy or acyl containing up to 4 carbon atoms; or a heterocyclic ring containing up to 6 atoms of which at least one is O, N or S, which ring is optionally bonded via alkyl containing up to 4 carbon atoms,P PWHICH INHIBIT THE METAMORPHOSIS OF ARTHROPODS.
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机译:式## STR1 ##的N-取代的氨基巴豆酸酯,其中R 1是氢,或具有至多4个碳原子的烷基或烯基; P P 2 R 3是直链-碳原子数最多为9的链或支链烷基或烯基,可选地被O或S中断,并任选地被卤素,苯氧基,二甲基氨基,环烷基或烯基取代,且碳原子数最多为8,其可被卤素,二甲基氨基或具有最多4个碳原子的烷基,烷氧基或烷硫基,可被卤素,二甲氨基,苯氧基或最多包含4个碳原子的烷基,烯基,酰基,烷氧基,烯氧基或炔氧基取代的苯基,或5-或6-包含至少一个O,S或N杂原子并且任选地被最多含4个碳原子或R 2的卤素,烷基或烷氧基取代的三元杂环是具有最多8个碳原子的环状烷基或烯基被卤素,二甲氨基或烷基,烷氧基或烷硫基取代,最多至4 ca碳原子;任选地被卤素,二甲氨基,苯氧基或烷基,烯基,酰基,烷氧基,烯氧基或炔氧基取代的苯基,其最多含4个碳原子;或含有至少一个O,S或N杂原子并任选地被卤素或含至多4个碳原子的烷基或烷氧基取代的5或6元杂环;或或P P R 1和R 2与相邻的氮原子一起形成杂环结构,该杂环结构可选地被具有1-4个碳原子的低级烷基取代并且除氮外还任选地包含其他杂原子,和