Substd s-triazolo-pyrazines for bronchospasm prevention - contg 3-acetamido-6-methyl-8-propyl-s-triazolo(4,3-a)pyrazine potentiated by atropine or hyoscine

摘要

Therapeutic compsns. for preventing bronchospasm are new, comprising 3-acetamido-6-methyl-8-propyl-s-triazolo 4,3-a pyrazine and atropine or hyoscine or one of their salts and a diluent. The triazolo-pyrazine is potentiated by atropine or hyoscine. Oral administration is pref. the dose of triazolopyrazine being 0.2-10 mg/kg and that of atropine or hyoscine 0.0002 to 0.05 mg/kg usually admin. as sulphate hydrobromide, methonitrate or methobromide. A unit dose of the compsn. contains 15-150 mg of triazolo-pyrazine (A) (I) and 0.02-1 mg of hyoscine or atropine (II) esp. 50 mg of (A) and 0.6 mg of (B). The compsns. have been tested and synergy demonstrated against carbachol-induced bronchospasm in the guinea-pig.