An improved .sup.82 Sr-.sup.82 Rb radioisotope generator system, based upon the complexing ion exchange resin Chelex-100, has been developed. Columns of this material can be easily and rapidly milked, and the Rb-Sr separation factor for a fresh generator was found to be 10. sup.7. Approximately 80 percent of the .sup.82 Rb present was delivered in a 15- ml volume of aqueous 0.2 M NH.sub.4 Cl solution. After more than 6 liters of eluant had been put through the generator, the Rb-Sr separation factor was still observed to be 10.sup.5, and no unusual strontium breakthrough behavior was seen in the system over nearly three . sup.82 Sr half lives.
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