Vasodilating and antihypertensive compositions and methods of effecting vasodilation and treating hypertension utilizing 2-amino-4H pyrane as the active agent

摘要

2-Amino-4 H-pyrane derivatives of the formulaPP WHEREINPP R.sup.1 and R.sup.2 are the same of different and each is hydrogen or straight- or branched-chain alkyl;P PR.sup.3 is straight- or branched-chain alkyl, phenyl or --COOR' wherein R' is a straight, branched or cyclic saturated or unsaturated aliphatic hydrocarbon;PP R.sup.4 is straight, branched or cyclic alkyl or alkenyl, aryl unsubstituted or substituted by 1, 2 or 3 of the same or different substituents selected from the group consisting of akyl, alkoxy, halogen, nitro, cyao, trifluoromethyl, carbalkoxy, and -- SO.sub.n alkyl wherein n is 0, 1 or 2, orPPR.sup.4 is naphthyl, quinolyl, pyridyl, thienyl or furyl unsubstituted or substituted by alkyl, alkoxy or halogen;PPR.sup.5 is straight, branched or cyclic alkyl or --OR" wherein R" is a straight, branched or cyclic hydrocarbon or said hydrocarbon interrupted by 1 or 2 oxygen atoms; andPPR.sup.6 is hydrogen or alkyl;P PARE USEFUL FOR THEIR STRONG CORONARY ACTION AND AS ANTIHYPERTENSIVE AGENTS.PPThis is a division of parent application Ser. No. 375,809, filed July 2, 1973 now U.S. Pat. No. 3,897, 462, issued on July 29, 1975.